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KMID : 0613820170270080937
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Journal of Life Science
2017 Volume.27 No. 8 p.937 ~ p.944
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Hypolipidemic and Hypoinsulinemic Effects of Dietary Fiber from Agar in C57BL/6N Mice Fed a High-fat Diet
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Park Jin-Ju
Kim Ji-Eun
Yun Woo-Bin
Lee Mi-Rim
Choi Jun-Young
Song Bo-Ram
Kim Dong-Seob
Lee Chung-Yeoul
Lee Hee-Seob
Lim Yong
Jung Min-Wook
Hwang Dae-Youn
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Abstract
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To investigate the beneficial effects of fiber derived from agar on the lipid and glucose metabolism of obese model mice, changes in the fat accumulation, lipid content, and insulin concentration were measured in C57BL/6N mice fed a high-fat diet (HFD) and treated with a beverage containing agar (BCA) for 9 weeks. The feed efficiency ratio was significantly decreased in the HFD+BCA treatment group, although the body weight and food intake were maintained a constant level. Also, the fat accumulation in the fatty tissue and liver were lower in the HFD+BCA treatment group than in the HFD+Vehicle treatment group. Furthermore, a significant decrease was detected in the levels of total cholesterol (TC) and LDL after the BCA treatment, while a constant HDL level was maintained in the same group. Moreover, the serum insulin concentration was significantly decreased in the HFD+ BCALo (Low concentration) and HFD+BCAMi (Middle concentration) groups compared to the HFD+ Vehicle group. Therefore, the results suggest that the long-term administration of dietary fiber from agar can improve fat accumulation in the fatty tissue and liver, the serum lipid profile, and the insulin concentration in the blood. Also, the results provide evidence that the inclusion of agar fiber in beverages results in significant hypolipidemic and hypoinsulinemic effects.
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KEYWORD
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Anti-obesity, Agar, dietary fiber, high-fat diet, hypolipidemic effect
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